Injection Route and TLR9 Agonist Addition Significantly Impact Heroin Vaccine Efficacy

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Injection Route and TLR9 Agonist Addition Significantly Impact Heroin Vaccine Efficacy

Active immunization is an effective means of blocking the pharmacodynamic effects of drugs and holds promise as a treatment for heroin addiction. Previously, we demonstrated the efficacy of our first-generation vaccine in blocking heroin self-administration in rats, however, many vaccine components can be modified to further improve performance. Herein we examine the effects of varying heroin v...

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ژورنال

عنوان ژورنال: Molecular Pharmaceutics

سال: 2014

ISSN: 1543-8384,1543-8392

DOI: 10.1021/mp400631w